2026 SIAM Conference on Life Sciences (LS26)

Learning Your Abc's: Improving Phylodynamic Inference Methods with Global Sensitivity Analysis

Nate Kornetzke

Determining Parameter Impact in Systems Biology Models Via Sensitivity Analysis: a Comparative Approach

Kelsey Gasior

Modeling Vulnerability to Thermal Stress in Exaiptasia Diaphana

Steve Williams

Using Sensitivity Analysis and Modeling to Study the Effects of Combination Immunotherapy on Triple-Negative Breast Cancer

Dayton Syme

Structure-Preserving Neural Surrogate for Long-Time Molecular Dynamics

Additi Pandey

Neural Operator Identification of Mechanobiological Drivers of Thoracic Aortic Aneurysm Using Local Dilatation and Distensibility

David Li

Multi-Fidelity Deep Learning for Estimation of Infarcted Myocardium From Strain Imaging

Raza Mehdi

Scientific Machine Learning for Cardiopulmonary Digital Twins: From Lumped-Parameter Models to Real-Time Icu Decision Support

A Domain Decomposition Method for Solution of a Pde-Constrained Generalized Nash Equilibrium Model of Biofilm Community Metabolism

Daniel B. Szyld, Isaac Klapper, Tianyu Zhang

Advection–Diffusion with Flow in Moving Cell Domains: Immersed-Boundary Models of Actin-Driven Migration

Lingxing Yao

Modeling Cardiac Electro-Fluid-Mechanics

Laura A. Miller

Heart-Rate Variability and Turbulence Onset in the Equine Aorta

Physics-Informed Random Features Model for Solving Partial Differential Equations

Chunyang Liao

Pde-Ode Models for Collective Dynamics in Go-Or-Grow Populations.

Ryan Thiessen

Collective Behavior in Social Mobilization: Multilayer Online–Offline Dynamics on Networks

Moyi Tian, Nancy Rodríguez, P. Jeffrey Brantingham

Correspondences Between Interacting Birth-Death Processes and the One-Dimensional Moran Model: Constraint Approximations and Fixation Times

Tom Chou

Learning Drift and Noise from Observing Stochastic Dynamics with Complex Noise Structures

Ziheng Guo, James Greene, Ming Zhong

Parameter Estimation in An Agent-Based Model of Zebrafish Through Pair Correlation Functions

Asini A. Konpola, Alexandria Volkening

Learning Environmental and Interaction Dynamics in Collective Behavior

James Greene

Mathematical Tools for Understanding Homeostasis in Biological Networks

Yangyang Wang, Fernando Antoneli, Martin Golubitsky, Zhengyuan Huang, Xinni Lin, Hillel Chiel, Jeffrey P. Gill, Peter Thomas

Homeostasis Patterns and Mode Interactions

Jiaxin Jin, William Duncan, Fernando Antoneli, Janet Best, Martin Golubitsky, Michael C. Reed, Frederick Nijhout, Ian Stewart

Period Homeostasis Near a Hopf Bifurcation

Steven Manns, Janet Best, Martin Golubitsky

Dynamics of Discrete Multi-State Models with Nonexpanding Global Transition Function and Applications to Iron Homeostasis

Julia Chifman

Using a Computational Model of COVID-19–induced Changes in Breathing to Inform Clinical Care

Christopher G. Wilson, Peter Thomas, Ellison O'Grady, Casey Diekman

Feedback Regulation of Physiological Limit Cycle Systems Via Averaging

Quevin Ip Morais, Peter J. Thomas

Data-Driven Modeling of Closed-Loop Respiratory Control

Ellison O’Grady, Casey Diekman, Peter J. Thomas, Christopher G. Wilson

Dynamical Breathing: Neuromodulation and Sensorimotor Integration in the Respiratory Network

Rishi R. Dhingra, Gjinovefa Kola, Samuel Qin, Peter J. Thomas, Mathias Dutschmann

Modern Equation Learning in the Life Sciences

David M. Bortz, Vanja Dukic

Highlighting and Overcoming Challenges Associated With Data-driven Modeling for Agent-based Models

John Nardini

Ddmo - A Python Package for Data-Driven Parametric Modeling

Susanne Fuerst

Fokker-Planck-Inverse Reinforcement Learning: A Physics-Constrained Approach to Markov Decision Process Models of Cell Dynamics

Identifiability and Physics-Informed Learning of Spatially Varying Stochastic Dynamics from Static Snapshots

Rebecca Gu, Zirui Zhang

From Static Patterns to Dynamical Systems, One Shot Learning Fro M Collective Behaviors

Ming Zhong, Yajie Ji, Baoli Hao, Mauro Maggioni

Weak Form Learning for Mean-Field Partial Differential Equations: An Application to Insect Movement

Seth O. Minor, Bret Elderd, Ben Van Allen, David M. Bortz, Vanja Dukic

Weak-form Methods in Statistical Modeling

Vanja Dukic, David M. Bortz

Geometric and Topological Approaches to Proteus Mirabilis Swarm Characterization

Morgan Byers, Eliotte Garling, Elizabeth Bradley, Karine Gibbs, James D. Meiss

A Curvature-Based Method to Recover Manifold Structure and Clusters in High-Dimensional Data

Exploring the Topological Shape of Plant Data

Erik J. Amezquita

Topological Data Analysis of Zebrafish Skin Patterns

Nour Khoudari, John Nardini, Alexandria Volkening

Persistent Homology of Functional Connectivity Predicts Fatigue in Prolonged Wakefulness

Yangyang Du, Alisa Huskey, Jung Won Cha, David Negelsman, William Killgore, Daniel Forger

Identifying Actin Asters and Rings Using Persistent Homology

Symmetry in Shape and Data Through the Euler Characteristic Transform

Ai-Driven Topological Data Analysis of Intracranial EEG in Epilepsy

Katrina Prantzalos

Data-informed Modeling of Biological Systems And an Example From Visual Neuroscience

Kevin K. Lin, Lai-Sang Young

Accuracy Vs. Understanding: Interpretable Decoding of Social Context in the Amygdala

Alexa N. Aucoin

Timescale Localization and Signal Propagation in Large-Scale Cortical Networks

Guanchun Li

Reproducing C. Elegans Premotor Neural Dynamics with a Biology-Based Network Model

Megan Morrison

Theory and Algorithms for Constructing AI-Based Dynamic Virtual Cells

Yuhao Sun

Generative Learning for Parameter Landscape Beyond Low-dimensionality

Zhuo-Cheng Xiao

Geometry of Neural Population Dynamics in Recurrent Networks: Why Linear Theory Fits Nonlinear Data

Yu Hu

Reconstructing Actin Dynamics of the Leading Edge from Observational Data

Wenzheng Shi, Alex Mogilner

First Passage Times to T Cell Activation

Maria D'Orsogna, Tom Chou, Tony Wong

Mechanical Forces Modulate Dwell Time Fluctuations to Optimize T-cell Activation

Arup Biswas

Intermittent Diffusion Enables Fast Dna Target Finding

Tory Richardson, Sean D. Lawley

Advances in Numerical Computation and Asymptotic Analysis for Cellular Signaling Problems

Alan E. Lindsay, Andrew J. Bernoff, Michael J. Ward, Jeremy Hoskins

Extreme Survival Trajectories for Populations of Identical Random Walkers

Extreme First Passage Times with Fast Immigration

Hwai-Ray Tung, Sean D. Lawley

Branching Under First-Passage Resetting

Aanjaneya Kumar

Modelling Cellular Resource Accumulation Using Queueing Theory

Jose Giral-Barajas, Paul C. Bressloff

Dynamic Redundancy and Mortality in Stochastic Search

EpiHiper: Recent Advances in Large-Scale, Networked, Computational Epidemiology

Stefan Hoops, Henning Mortveit, Jiangzhuo Chen

Scalable Agent-Based Modeling with the Memilio Framework

Carlotta Gerstein, Sascha Korf, Julia Bicker, David Kerkmann, Martin Kühn

Using Person Trajectories in Order to Quantify Exposure-Based Health Impacts

Sydney C. Paltra

A Semi-Continuous Graph-Ode Approach with Flow-Based Formulations to Avoid Quadratic System Growth in Lagrangian Metapopulation Models

Henrik Zunker

Leveraging the Laser (Light-Agent Spatial Model for Eradication) Modeling Framework to Explore Strategies in the Type 2 Poliovirus Endgame

Steve Kroiss

Metaverse Demystified: Lessons Learned from Using PatchSim for Pandemic and Epidemic Response Support

Srini Venkatramanan, Przemek Porebski, Bryan Lewis, Madhav Marathe

Quantifying Drug Treatment Effects on Spleen Red Blood Cell Filtration Using Multi-fidelity Neural Network with Applications to Sickle Cell Disease

Guansheng Li

Integrating Poroelastic Simulations and Machine Learning for Mechanical Parameter Identification of Porcine Lungs

Mingchao Cai, Edwin Aigbokhan, Olusola Olabanjo, Emmanuel Akor, David Kaczka

BrainACTL: Adaptive Temporal Brain Connectivity Learning for Functional Link Prediction and Age Estimation

Yiran Huang, Amirhossein Nouranizadeh, Data Science, Christine Ahrends, Mengjia Xu

Graph Neural Network-Based Prediction of Axial Stress in Fibrin Networks of Blood Clot

Beikang Gu

Ai-Enabled Physics Driven Models for Quantitative Systems Pharmacology

Ravi Radhakrishnan

Efficient Modeling of Bio-Molecular Kinetics with Random Features

Feliks Nueske

Machine-learning Integration of Clot Growth and Thrombin Generation Simulations Into PK-PD Anticoagulant Models

Anass Bouchnita

Data-Driven Modeling of Heart Valve Biomechanics Using Transformer-Based Neural Operators

Shawn J. Koohy, Wensi Wu, Paris Perdikaris

From Molecules to Networks: Multiscale Modeling of Rho GTPase Signaling

Adriana Dawes, Liam D. O'Brien, Natalia Kravtsova

Abstracting Gene Regulatory Logic: How 'teams' Reveal Design Principles Driving Cancer Metastasis

Kishore Hari, Mohit Kumar Jolly, Herbert Levine

Multi-Omics Methodological Framework to Redefine Disease Endotypes and Therapeutic Determinants in Dermatology

Sungrim Seirin-Lee

The Estrogen Advantage: A Hormonal Key to Blood Pressure Control?

Anita Layton

Generating Sex-Specific Models of Lung Immunity to Improve Patient Treatment.

Jason Shoemaker

Quantitative Systems Pharmacology Model of B-Cell Dynamics for B-Cell Targeting Therapies.

Yue Fang, Rohit Rao, Allen Richard, Nessy Tania

Mathematical Modeling As a Common Language: Seamless Integration from Basic Biological Principles to Clinical Practice and Drug Development

Miyoshi So

Making Math into Medicine: Math Application to and Impact on the Pharmaceutical Industry

Real-MVP: Virtual Populations As Simulation-Based Conditional Neural Densities

Shayan Hajhashemi

Virtual Patient Simulations for Optimizing Virologic Endpoints in Antiviral Clinical Trials

Chenhui Ma

Developing Virtual Patients for Advancing Clinical Trial Design Via Biology-Based Modeling.

Gauri Patel, David A. Hormuth II, Reshmi J.S. Patel, Ernesto A.B.A.F Lima, Anirban Chaudhuri, Joe Kileel, Thomas E. Yankeelov

Bridging Virtual Populations and Digital Twins Through Bidirectional Patient Translation Using Variational Autoencoders

Kiyoto Tanemura

Personalization of Medical Digital Twins

Logan Rose, Boris Aguilar, Juho Kim, David Murrugarra, Jing Qin, Jonathan Martinez

GBM-FORECAST: Predicting recurrence in glioblastoma using serial white blood cell counts

Chengyue Wu, Ernesto Lima, Casey Stowers, Zhan Xu, Clinton Yam, Jong Bum Son, Jingfei Ma, Gaiane Rauch, Thomas Yankeelov

Toward Development and Deployment of MRI-guided Digital Twins for Neoadjuvant Therapy of Triple Negative Breast Cancer

Schedule Optimization for Treatment of Acute Myeloid Leukemia with Venetoclax/Azacitidine using Digital Twin Models

Yue Zhang, Boris Aguilar

Mathematical Modeling of Bone Remodeling After Surgical Menopause

Ashlee N. Ford Versypt, Anna C. Nelson, Edwina Yeo, Yun Zhang, Carley Cook, Sophie Fischer-Holzhausen, Lauryn Keeler Bruce, Pritha Dutta, Samaneh Gholami, Brenda Smith

Modeling Progesterone Dynamics and Its Impact on Recovery Following Mild Traumatic Brain Injury in Women

Alexa Shreeve, Nathan Cahill

Integration of Estrogen into Cell Signaling Models of Valve Interstitial Cells

Daniel Howsmon

Modeling Estrogen-Mediated Effects on Sleep Quality

Shelby Stowe, Thomas Scammell, Dmitri Volfson, Cecilia Diniz Behn

Mathematical Modeling to Inform Automated Insulin Delivery for Women With Type 1 Diabetes: A Model-based Digital Twin Approach Addressing Menstrual Cycle-related Metabolic Variability.

Multiscale Model of Uterine Adaptation During Pregnancy

Emily Hoffmann, Kyoko Yoshida

Systems Immunology at the Maternal-Fetal Interface

Sepideh Dolatshahi

A Fractional Modeling Approach to Oxidative Stress–Driven Cellular Aging and Its Impact on Female Fertility

Modeling the Impact of Human Behavior on Sars-CoV-2 Transmission Dynamics

Binod Pant

Modelling Waning Immunity

Jane Marie Heffernan

Pertussis Transmission Dynamics and Demographic Shifts under Evolving Vaccination Programs and the Benefits of Adult Boosting

Qing Han

Phylogeny-Informed Modeling and Control Analysis of H5N1 Transmission Across Wild Bird, Poultry, and Human Populations

Oluwatosin Babasola

Heterogeneity in Epidemic Dynamics: Modeling Disease Spread in Complex Populations

Haridas Kumar Das

Modeling Reveals Azd5582-Reactivated Cells Differ from Productively Infected Cells

Tin Phan

Resolving Gradient Pathology in Physics-Informed Epidemiological Models

Woldegebriel Assefa Woldegerima

Within and Between-Host Epidemic Modeling

Angela Tower

Development of Platelet Aggregates at High Shear Rate Driven by Von Willebrand Factor

Keshav Patel

Quantifying Thrombus Failure and Embolization at High Shear Rates

Aaron Barrett

Infraslow Rhythms in NREM-REM Sleep Cycling

Victoria Booth, Cecilia Diniz Behn, Franz Weber

Infraslow Oscillations and the Dynamics of Noradrenaline

Cecilia Diniz Behn, Alejandro Osorio-Ferero, Franz Weber, Victoria Booth

Adaptation Via Integral Control in Engineered Biomolecular Networks

Domitilla Del Vecchio

From Spike Shape to Burst(lets): Activity-Dependent Control of Respiratory Rhythm and Pattern Generation

Ryan Phillips, Jonathan E. Rubin

Weak Sindy for Identification and Parameterization of Transport Models for Interstitial Fluid Flows in Solid Cancers

Ryan Woodall, Cora Esparza, Jessica Cunningham, Maosen Wang, Alex Brummer, Jonathan Hibbard, Margarita Gutova, Christine Brown, Jennifer Munson, Russell Rockne

Integrating Weak Form Equation Learning Within a Bayesian Hierarchical Framework for Species Distribution Modeling

Peter Burke, Katherine Dixon, Carlos Polivka, Gregory Dwyer, Vanja Dukic

Multi-Objective Bayesian Inference in a Stochastic Agent-Based Model of Zebrafish Pattern Formation Via Topological Data Analysis

Yue Liu, Alexandria Volkening

Data-Driven Extensions to An Ensemble Kalman Filter-Based Algorithm for Personalizing Agent-Based Models

Daniel Cruz, Adam Knapp, Reinhard C. Laubenbacher, Borna Mehrad

Predictive Biology in Crops: Bridging the Genotype to Phenotype (G2P) Gap

Scalable Feature Extraction and AI/ML for AgriTech Innovation

Resource Accumulation by Ideal Collectives in Stochastic Environments

Hyunjoong Kim, Zachary P. Kilpatrick, Kresimir Josic

Gated First-Passage Processes

Yuval Scher

Bridging from Detailed Networked Models to Patch Models - Thoughts and Illustrations.

Henning S. Mortveit, Stefan Hoops, Caroline Jareb, Simrat Saini

Linking Time-Series, Patch, and Agent-Based Models of Measles in Laser, with Applications to Measles Transmission in Nigeria

Katherine Rosenfeld, Qifang Bi, Kevin McCarthy, Christopher Lorton, Jonathan Bloedow

Knowledge Graph-Driven Ai in Life Sciences: Case Studies in Kinase-Substrate Association Prediction and Veteran Suicide Risk Assessment

Chuming Chen, Manju Anandakrishnan, Cathy Wu

Machine Learning for Image Based Reconstruction of Patient Cardiac Blood Flow

Fanwei Kong

QSP Models in Inflammation and Immunology: Introduction and Case Studies

Cole Zmurchok, Ahmed Elmokadem, Yuezhe Li, Daniel Kirouac

Mechanistic Insights by Combining QSP and ML: An Inflammatory Bowel Disease Case Study

Yamato Sano, Bryce Johnson, Valerie Clerin, Richard Allen, Nessy Tania

Dynamics of Clonal Evolution in the Hematopoietic System and Associated Malignancies

Sydney Ackerman, Dominik Wodarz

Stochastic Models and Time Series Data for Leukemia Evolution

Russell Rockne

Discovering Minimal Stimulation Patterns for Reentry in Excitable Media via Reinforcement Learning

Thomas Bury

The Effect of Intercell Ephaptic Coupling on the Scale Length of Spiral Wave Turbulence in the Heart

Niels Otani, Seth H. Weinberg